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KMID : 1035220210130010015
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Korean Journal of Neuromuscular Disorders
2021 Volume.13 No. 1 p.15 ~ p.19
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Statin-Naive Paraneoplastic Anti-HMGCR Myopathy
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Yung Young-Bok
Kim Bo-Young
Oh Ki-Chang
Cho Joong-Yang
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Abstract
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Anti-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (anti-HMGCR) myopathy is a subtype of immune-mediated necrotizing myopathy regardless of exposure to statins. Necrotizing myopathy is distinguished by necrotic muscle fibers with a relative lack of inflammation. It is frequently associated with a high risk of permanent muscle damage and disability. Recent studies have suggested a slightly increased risk of cancer in patients with anti-HMGCR myopathy. This report describes a case of statin-naive paraneoplastic anti-HMGCR myopathy, with rapidly progressive muscle weakness leading to respiratory failure.
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KEYWORD
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Anti-HMGCR, Necrotizing myopathy, Statin-naive
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